Indiana vs Ohio State Prediction 12/6/2025 Today’s College Football Picks

In this article, we will formulate an Indiana vs Ohio State Prediction for this College Football Big Ten Championship game on Saturday, December 6th. Let’s take a look at the prediction for this College Football matchup.

Ohio State Buckeyes Preview

Ohio State has a 12-0 record this season and finished 1st in the Big Ten. They are coming off a 27-9 road win against Michigan. Offensively, Ohio State averages 37 points per game, ranking 13th in the nation, while defensively, they allow 7.8 points per game, which is 1st. Ohio State averages 438.5 total yards per game (267 passing and 171.5 rushing), while allowing 203 total yards per game (81.7 rushing and 121.3 passing).

Julian Sayin leads Ohio State with 3,065 passing yards with 78.9% completed passes and 30 touchdowns. Bo Jackson leads the team in rushing yards with 952, while Jeremiah Smith has a team-high 72 receptions for 942 receiving yards. Defensively, Sonny Styles has a team-high 68 total tackles (38 of them solo), while Caden Curry leads the team in sacks, with 9, and Caleb Downs, Jermaine Matthews Jr. and Payton Pierce lead the team with 2 interceptions each.

Indiana Hoosiers Preview

Indiana has a 12-0 record this season and finished 1st in the Big Ten. They are coming off a 56-3 road win against Purdue. Offensively, Indiana averages 44.3 points per game, ranking 2nd in the nation, while defensively, they allow 10.9 points per game, which is 2nd. Indiana averages 483.8 total yards per game (254.1 passing and 229.8 rushing), while allowing 251.8 total yards per game (79.3 rushing and 172.5 passing).

Fernando Mendoza leads Indiana with 2,758 passing yards with 72% completed passes and 32 touchdowns. Roman Hemby leads the team in rushing yards with 866, while Omar Cooper Jr. has a team-high 58 receptions for 804 receiving yards. Defensively, Rolijah Hardy has a team-high 76 total tackles (35 of them solo), while Stephen Daley leads the team in sacks, with 4.5, and Louis Moore has a team-high 5 interceptions.

Indiana Hoosiers @ Ohio State Buckeyes Betting Trends: Conference Championships

Why the Ohio State Buckeyes will win

• Ohio State has won each of its last eight games against top-15 AP-ranked teams.
• Indiana has lost 15 of its last 16 games against teams from Ohio.
• Ohio State has covered the spread in each of its last nine games against AP-ranked teams.
• Indiana has failed to cover the spread in six of its last seven games against teams from Ohio.
• Ohio State has won the first quarter in six of its last eight games against conference opponents.
• Ohio State has won the first half in each of its last 10 games against conference opponents.

Why the Indiana Hoosiers will win

• Indiana has won each of its last 12 games.
• Ohio State has failed to cover the spread in three of its last four games in Indiana.
• Indiana has won the first quarter in each of its last 12 games against conference opponents.
• Indiana has won the first half in each of its last seven games against conference opponents.

Total Points Facts

• Ten of Indiana’s last 11 games against teams from Ohio have gone OVER the total points line.
• Seven of the last eight games between Indiana and Ohio State have gone OVER the total points line.

Ohio State Buckeyes Player Prop Facts

• Heading into the Conference Championships, Julian Sayin ranks 2nd amongst qualified players for passer rating (129.9) this season.

Indiana Hoosiers Player Prop Facts

• Heading into the Conference Championships, Fernando Mendoza ranks 1st amongst FBS players for passing touchdowns (32) this season.

Matchup/League Facts

• Ohio State ranks 1st among FBS teams for points allowed per game this season (7.8).
• Ohio State ranks 1st among FBS teams for Q1 opponent points per game this season (1.0).
• Indiana has recorded the equal-most home wins by a margin of 10+ points of any FBS team this season (7).
• Indiana has recorded the equal-most home wins by a margin of 35+ points of any FBS team this season (4).

Indiana vs Ohio State Prediction

In this Indiana vs Ohio State Prediction, Ohio State is coming as -4.5-point home favorites. Both teams were excellent in the regular season, as they both finished their campaigns undefeated. Ohio State was almost perfect against the spread with a 10-1 record, while Indiana was 7-5 against the spread. Indiana has the second-best offense in the whole country, but those two teams are the best in the nation defensively, holding their opponents into just 17.8 points per game combined. With this being a playoff game, I expect an extremely tight game between the two best defenses of the country, so go under the 48 points in this one.

Nikos Lagouretos's Pick: Under 48