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Fresno State vs USC Prediction 9/4/2026 Today’s College Football Picks

Aug 29, 2026; Los Angeles, California, USA; Southern California Trojans quarterback Jayden Maiava (14) throws the ball against the San Jose State Spartans at United Airlines Field at Los Angeles Memorial Coliseum. Mandatory Credit: Kirby Lee-Imagn Images

Aug 29, 2026; Los Angeles, California, USA; Southern California Trojans quarterback Jayden Maiava (14) throws the ball against the San Jose State Spartans at United Airlines Field at Los Angeles Memorial Coliseum. Mandatory Credit: Kirby Lee-Imagn Images

MATCHUP Fresno State Bulldogs USC Trojans
Team Records 0-0 1-0
Spread +22.5 -112 -22.5 -108
Moneyline +1200 -2400
Total Over 51.5 (-115) Under 51.5 (-105)
Where Los Angeles Memorial Coliseum, Los Angeles, CA
When Friday, September 4, 2026
Time 09:00 PM EDT
TV FOX
The Fresno State Bulldogs and USC Trojans meet Friday in college football action at Los Angeles Memorial Coliseum. Here’s a Fresno State vs USC Prediction. This article will include a Fresno State vs USC Pick.

Fresno State Bulldogs Betting Preview


Fresno State won nine games last season and enters the second year under coach Matt Entz. Fresno State has won at least six games in each of the last five years.

Fresno State returns its top playmakers at running back (Rayshon Luke) and wide receiver (Josiah Freeman). It’s a question of who will win the starting quarterback job between Khristian Martin and Jayden Mandal. Whoever wins it will have players they can rely on to take off pressure. Fresno State was elite defensively last season, and defensive coordinator Nick Benedetto is back for another season. Simeon Harris and K’vion Thunderbird are the standouts of this group, while Tytus Khajavi has breakout potential at linebacker. Fresno State is coached well and has difference makers on both sides of the ball. The Bulldogs shouldn’t be slept on at any point in the season.

USC Trojans Betting Preview


The USC Trojans beat San Jose State, and they play Louisiana and Rutgers next. The USC Trojans look for a fifth straight 2-0 start to the college football season. Jayden Maiava is completing 86.2 percent of his passes for 286 yards, 2 touchdowns, and 0 interceptions. Trent Mosley and Tron Baker have combined for 163 receiving yards and 1 touchdown, while Corey Simms has 4 receptions.

The USC Trojans’ ground game is averaging 164 yards per contest, and King Miller leads the way with 63 yards and 1 touchdown. Defensively, USC is allowing 26 points and 336 yards per game. Jide Abasiri leads the USC Trojans with 4 tackles, Jadyn Ramos has 1 sack, and Luke Wafle has 1 pass deflection.

Why the USC Trojans will win

Why the Fresno State Bulldogs will win

Total Points Facts

USC Trojans Player Prop Facts

Fresno State Bulldogs Player Prop Facts

Matchup/League Facts

Fresno State vs USC Prediction


I like the fact that USC has had a chance to get a game under its belt and get the jitters out of the way. There’s value in that. However, this is a lot of points to give a good Fresno State team that has playmakers on offense and can be elite defensively. Fresno State is not a pushover, as this is a team that went into Boise State last year and left with a blowout win. Let’s also not act as if we didn’t just see USC allow San Jose State to hang around. I’m just higher on Fresno State than most, I guess, as I just don’t believe this is a pushover team. I’ll grab the free touchdowns with the Bulldogs.

Randy Chambers's Pick: Fresno State +22.5

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