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Florida State vs Clemson Prediction 11/8/2025 Today’s College Football Picks

Nov 1, 2025; Clemson, South Carolina, USA; Duke Blue Devils safety Ma'Khi Jones (26) goes to tackle Clemson Tigers running back Adam Randall (8) during the game at Memorial Stadium. Mandatory Credit: Alex Martin-Imagn Images

Nov 1, 2025; Clemson, South Carolina, USA; Duke Blue Devils safety Ma'Khi Jones (26) goes to tackle Clemson Tigers running back Adam Randall (8) during the game at Memorial Stadium. Mandatory Credit: Alex Martin-Imagn Images

MATCHUP Seminoles Florida State Tigers Clemson
Team Records 4-4 3-5
Spread +1.5 -108 -1.5 -112
Moneyline -105 -115
Total Over 56.5 (-110) Under 56.5 (-110)
Where Memorial Stadium (Clemson, SC), Clemson, SC
When Saturday, November 8, 2025
Time 07:00 PM EST
TV ACC Network
The Florida State Seminoles and Clemson Tigers meet Saturday in college football action at Memorial Stadium. Here’s a Florida State vs Clemson Prediction. This article will include a Florida State vs Clemson Pick.

Florida State Seminoles Betting Preview


The Florida State Seminoles lost to Stanford, beat Wake Forest, and they play Virginia Tech next. Florida State has lost 4 of its last 5 games. Tommy Castellanos is completing 61.5 percent of his passes for 1,878 yards, 10 touchdowns, and 5 interceptions. Duce Robinson and Micahi Danzy have combined for 1,192 receiving yards and 6 touchdowns, while Lawayne McCoy has 13 receptions.

The Florida State Seminoles ground game is averaging 241.3 yards per contest, and Gavin Sawchuk leads the way with 432 yards and 8 touchdowns. Defensively, Florida State is allowing 20.6 points and 316 yards per game. Earl Little Jr. leads the Florida State Seminoles with 52 tackles, Mandrell Desir has 3 sacks and Jerry Wilson has 2 interceptions.

Clemson Tigers Betting Preview


The Clemson Tigers lost to SMU and Duke, and they play Louisville next. Clemson has lost 4 of its last 6 games. Cade Klubnik is completing 67.2 percent of his passes for 1,915 yards, 13 touchdowns, and 5 interceptions. Bryant Wesco Jr. and T.J. Moore have combined for 1,036 receiving yards and 10 touchdowns, while Antonio Williams has 33 receptions.

The Clemson Tigers ground game is averaging 123.8 yards per contest, and Adam Randall leads the way with 522 yards and 6 touchdowns. Defensively, Clemson is allowing 24 points and 350.3 yards per game. Sammy Brown leads the Clemson Tigers with 58 tackles, Will Heldt has 4 sacks and Ricardo Jones has 3 interceptions.

Why the Clemson Tigers will win

Why the Florida State Seminoles will win

Total Points Facts

Clemson Tigers Player Prop Facts

Florida State Seminoles Player Prop Facts

Matchup/League Facts

Florida State vs Clemson Prediction


You can argue Florida State has had the better team and is the better team entering this game. However, the truth is I want nothing to do with either of these teams. Clemson has been the biggest underachiever on the season and is 2-6 ATS. With all of that said, we’re getting Clemson at home in a pick em spot, and Memorial Stadium is one of the toughest places in the country to play. This will be just the fourth time since 2011 where Clemson is a home favorite of 3 or fewer points. You don’t get this chance often. I’ll ride with Clemson on Saturday afternoon.

Randy Chambers's Pick: Clemson -1.5

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