Duke vs Virginia Prediction 12/6/2025 Today’s College Football Picks

The Virginia Cavaliers and the Duke Blue Devils meet in ACC Championship college football action from Bank of America Stadium on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Virginia Cavaliers vs. Duke Blue Devils prediction.

Virginia Cavaliers Recap

The Virginia Cavaliers come into this game looking to add on to their 10-2 mark in 2025, culminating with a 27-7 win over Virginia Tech in their regular season finale.

Cavaliers Looking For First ACC Title

Chandler Morris has thrown for 2,586 yards, 14 touchdowns and 7 interceptions on 65.9% passing along with 248 rushing yards and 5 TDs on the ground while J’Mari Taylor has rushed for a team-high 997 yards and 14 touchdowns so far this season to lead Virginia on the ground. Harrison Waylee has 422 rushing yards with 5 touchdowns while Xavier Brown has 241 rushing yards and a TD. Trell Harris leads the Cavaliers with 809 receiving yards and 5 TDs on 56 catches while Cam Ross has 43 grabs for 459 yards and 2 touchdowns. Jahmal Edrine also has 484 receiving yards with a TD while five more Cavaliers have 100+ receiving yards as well this season. On defense, Devin Neal has a team-high 70 total tackles while Daniel Rickert has a team-high 6 sacks this season. Mitchell Melton also has 5 sacks and Fisher Camac has 4.5 sacks. As a unit, Virginia has combined for 30 sacks and 12 interceptions so far this season. 

Duke Blue Devils Recap

The Duke Blue Devils come into this game looking to pull off the surprise of the year and make the college football playoff after finishing 7-5 on the year thanks to a 49-32 win over Wake Forest last time out.

Blue Devils Looking To Crash CFP

Darian Mensah has thrown for 3,450 yards, 28 touchdowns and 4 interceptions on 67.5% passing while Nate Sheppard has a team-high 865 rushing yards with 9 TDs and Anderson Castle has 435 rushing yards with 11 touchdowns. Cooper Barkate leads Duke’s receiving group with 63 catches for 978 yards and 6 touchdowns while Que’Sean Brown has 665 receiving yards with 3 TDs. Sahmir Hagans has 432 receiving yards with 6 scores and Jeremiah Hasley has 385 receiving yards as well this season. On defense, Caleb Weaver has a team-high 78 total tackles while Vincent Anthony Jr. has 6.5 sacks and Josiah Green has 3.5 sacks. As a unit, Duke’s defense has combined for 25 sacks and 11 interceptions so far this season.

Duke Blue Devils @ Virginia Cavaliers Betting Trends: Conference Championships

Why the Virginia Cavaliers will win

• Duke has lost each of its last 10 games against AP-ranked teams.
• Virginia has won nine of its last 10 games.
• Virginia has covered the spread in nine of its last 10 games against Duke.
• Duke has failed to cover the spread in each of its last five games against AP-ranked teams.
• Virginia has won the first quarter in eight of its last nine games against conference opponents.
• Virginia has won the first half in three of its last four games against conference opponents.

Why the Duke Blue Devils will win

• The underdog has won four of Duke’s last six games.
• Virginia has lost each of its last three games at neutral venues.
• Virginia has failed to cover the spread in each of its last four games as a favorite against teams from North Carolina.
• Duke has covered the spread in five of its last six games as an underdog in North Carolina.

Total Points Facts

• Seven of Duke’s last eight games as an underdog have gone OVER the total points line.
• Six of Virginia’s last seven games have gone UNDER the total points line.

Virginia Cavaliers Player Prop Facts

• Heading into the Conference Championships, Daniel Sparks ranks 6th amongst qualified players for gross average yards per punt (47.3) this season.

Duke Blue Devils Player Prop Facts

• Heading into the Conference Championships, Darian Mensah is one of only two players in the league to record two or more passing touchdowns in nine consecutive appearances this season.

Matchup/League Facts

• Virginia has played in the equal-highest number of games that went to overtime this season (3).
• Virginia ranks T8th among FBS teams for Q1 opponent points per game this season (2.3).
• Duke ranks 4th among FBS teams for 4th down conversion percentage this season (73.5).
• Duke ranks 131st among FBS teams for passing yards allowed per game this season (273.3).

Virginia Cavaliers vs. Duke Blue Devils Prediction

I’m on the Cavaliers here. I think Duke’s somewhat fortunate to be in the position that they’re in, and while it’s admittedly been a down year for the ACC, the Cavaliers have been the best of the bunch and I think this is a Cavaliers spot to finish the job and get to the CFP. Give me the Cavaliers laying the points.

Chris Ruffolo's Pick: Virginia -3.5