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Clemson vs South Carolina Prediction 11/29/2025 Today’s College Football Picks

Nov 15, 2025; College Station, Texas, USA; Texas A&M Aggies linebacker Taurean York (21) tackles South Carolina Gamecocks running back Rahsul Faison (1) during the third quarter at Kyle Field. Mandatory Credit: Troy Taormina-Imagn Images

Nov 15, 2025; College Station, Texas, USA; Texas A&M Aggies linebacker Taurean York (21) tackles South Carolina Gamecocks running back Rahsul Faison (1) during the third quarter at Kyle Field. Mandatory Credit: Troy Taormina-Imagn Images

MATCHUP Clemson Tigers South Carolina Gamecocks
Team Records 6-5 4-7
Spread +2.5 -105 -2.5 -115
Moneyline +120 -142
Total Over 46.5 (-108) Under 46.5 (-112)
Where Williams-Brice Stadium, Columbia, SC
When Saturday, November 29, 2025
Time 12:00 PM EST
TV SEC Network
The Clemson Tigers and South Carolina Gamecocks meet Saturday in college football action at Peden Stadium. Here’s a Clemson vs South Carolina Prediction. This article will include a Clemson vs South Carolina Pick.

Clemson Tigers Betting Preview


The Clemson Tigers beat Louisville and Furman. Clemson has won 3 straight games. Cade Klubnik is completing 67.2 percent of his passes for 2,482 yards, 16 touchdowns, and 5 interceptions. Antonio Williams and T.J. Moore have combined for 1,191 receiving yards and 8 touchdowns, while Bryant Wesco Jr. has 31 receptions.

The Clemson Tigers ground game is averaging 142.8 yards per contest, and Adam Randall leads the way with 677 yards and 8 touchdowns. Defensively, Clemson is allowing 23.1 points and 382.3 yards per game. Sammy Brown leads the Clemson Tigers with 82 tackles, Will Heldt has 6 sacks and Ricardo Jones has 4 interceptions.

South Carolina Gamecocks Betting Preview


The South Carolina Gamecocks lost to Texas A&M and beat Coastal Carolina. The South Carolina Gamecocks have lost 5 of their last 6 games. LaNorris Sellers is completing 61.8 percent of his passes for 2,056 yards, 11 touchdowns, and 6 interceptions. Vandrevius Jacobs and Nyck Harbor have combined for 910 receiving yards and 8 touchdowns, while Jayden Sellers has 17 receptions.

The South Carolina Gamecocks ground game is averaging 130.5 yards per contest, and Rahsul Faison leads the way with 433 yards and 3 touchdowns. Defensively, South Carolina is allowing 23.7 points and 382.1 yards per game. DQ Smith leads the South Carolina Gamecocks with 60 tackles, Bryan Thomas Jr. has 7 sacks and Gerald Kilgore has 2 interceptions.

Why the South Carolina Gamecocks will win

Why the Clemson Tigers will win

Total Points Facts

South Carolina Gamecocks Player Prop Facts

Clemson Tigers Player Prop Facts

Matchup/League Facts

Clemson vs South Carolina Prediction


This has been an underachieving season for Clemson, and we’ve money fading this group that’s also 4-6 ATS. However, I’m not sure what South Carolina has done to be favored. I get it’s a rivalry game and South Carolina is at home on senior night with 26 seniors, but the Gamecocks have arguably been even worse than Clemson this season. Clemson has at least won 3 straight games and has shown recent life on both sides of the ball.

Despite having a star capable quarterback, South Carolina is nonexistent offensively most weeks and has scored 14 or fewer points in 4 of its last 9 games. Clemson has won 8 of the last 10 games against South Carolina. Given the current form, I kind of expect Clemson to win this game outright. I’ll gladly take the points while snagging the ML as well.

Randy Chambers's Pick: Clemson +2.5

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