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Clemson vs North Carolina Prediction 10/4/2025 Today’s College Football Picks

Sep 20, 2025; Orlando, Florida, USA; North Carolina Tar Heels running back Demon June (12) catches a pass during the second half against the UCF Knightsat the Bounce House Stadium. Mandatory Credit: Mike Watters-Imagn Images

Sep 20, 2025; Orlando, Florida, USA; North Carolina Tar Heels running back Demon June (12) catches a pass during the second half against the UCF Knightsat the Bounce House Stadium. Mandatory Credit: Mike Watters-Imagn Images

MATCHUP Clemson Tigers North Carolina Tar Heels
Team Records 2-3 2-3
Where Kenan Stadium, Chapel Hill, NC
When Saturday, October 4, 2025
Time 12:00 PM EDT
TV ESPN

The Clemson Tigers and North Carolina Tar Heels meet Saturday in college football action at Kenan Stadium. Here’s a Clemson vs North Carolina Prediction. This article will include a Clemson vs North Carolina Pick.

Clemson Tigers Betting Preview

The Clemson Tigers lost to Georgia Tech and Syracuse, and they play Boston College next. Clemson has lost 4 of its last 5 games. Cade Klubnik is completing 60.1 percent of his passes for 996 yards, 6 touchdowns, and 4 interceptions. Bryant Wesco Jr. and T.J. Moore have combined for 553 receiving yards and 5 touchdowns, while Tyler Brown has 13 receptions.

The Clemson Tigers ground game is averaging 116.3 yards per contest, and Adam Randall leads the way with 338 yards and 3 touchdowns. Defensively, Clemson is allowing 22.8 points and 362 yards per game. Wade Woodaz leads the Clemson Tigers with 35 tackles, Will Heldt has 3 sacks and Ronan Hanafin has 1 interception.

North Carolina Tar Heels Betting Preview

The North Carolina Tar Heels beat Richmond, lost to UCF, and they play Cal next. North Carolina has lost 5 of its last 7 games. Gio Lopez is completing 62.7 percent of his passes for 430 yards, 3 touchdowns, and 3 interceptions. Jordan Shipp and Chris Culliver have combined for 307 receiving yards and 3 touchdowns, while Javarius Green has 6 receptions.

The North Carolina Tar Heels ground game is averaging 113.5 yards per contest, and Demon June leads the way with 250 yards and 1 touchdown. Defensively, North Carolina is allowing 22.8 points and 344.5 yards per game. Andrew Simpson leads the North Carolina Tar Heels with 28 tackles, Melkart Abou Jaoude has 2 sacks and Malcolm Ziglar has 1 interception.

Clemson Tigers @ North Carolina Tar Heels Betting Trends: Week 6

Why the North Carolina Tar Heels will win

Why the Clemson Tigers will win

Total Points Facts

North Carolina Tar Heels Player Prop Facts

Clemson Tigers Player Prop Facts

Matchup/League Facts

Clemson vs North Carolina Prediction

I know North Carolina isn’t a good team, as it’s led by one of the worst offenses in the country and has a head coach who may have watched the game pass him by. However, what in the world has Clemson done to deserve to be a double-digit favorite on the road? Clemson has 3 ugly losses and didn’t look convincing in its lone win against Troy. Clemson has underachieved on other sides of the ball and can’t be trusted at the moment. This line feels like oddsmakers haven’t been watching football this season. Clemson has also failed to cover each of its last 6 games as a double-digit favorite, and 2 of those games were outright losses. I’m going to grab the points with North Carolina at home.

Randy Chambers's Pick: North Carolina +14

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