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Clemson vs Boston College Prediction 10/11/2025 Today’s College Football Picks

Oct 4, 2025; Chapel Hill, North Carolina, USA; Clemson Tigers quarterback Cade Klubnik (2) with the ball as North Carolina Tar Heels defensive lineman CJ Mims (92) defends in the second quarter at Kenan Stadium. Mandatory Credit: Bob Donnan-Imagn Images

Oct 4, 2025; Chapel Hill, North Carolina, USA; Clemson Tigers quarterback Cade Klubnik (2) with the ball as North Carolina Tar Heels defensive lineman CJ Mims (92) defends in the second quarter at Kenan Stadium. Mandatory Credit: Bob Donnan-Imagn Images

Clemson (2-3) vs Boston College (1-4)

October 11, 2025 at 07:30 PM EDT

The Line: Betting Odds: Boston College +14.5 — Over/Under: +55

(Get latest betting odds)

In this article we will formulate a Clemson vs Boston College prediction for this College Football game on Saturday, October 11th at Alumni Stadium in Chestnut Hill, Massachusetts. Let’s take a look at the prediction for this week 7 matchup. 

Clemson Tigers Betting Preview

The Clemson Tigers are 2-3 (1-2) this year after they defeated North Carolina by a score of 38-10 last week. Clemson led 28-3 after the first quarter and they were able to cruise to the very easy victory in the second half. The Tigers out gained UNC by a total of 488-270, went 4-12 on third downs, and lost the turnover battle by a total of 1–0 in the game. Cade Klubnik went 22-24 for 254 yards and four touchdowns, while Adam Randall rushed eight times for 30 yards. TJ Moore led the receivers with five receptions for 108 yards and one score in the game. The Clemson defense recorded one sack and six tackles for loss in the victory. 

Prior to that win, the Tigers lost to Syracuse, Georgia Tech, and LSU, but did beat Troy in their second game. Clemson is averaging 23.4 points per game with 279.0 passing yards and 110.8 rushing yards per game, while they are allowing 20.2 points against per game this season. Cade Klubnik has completed 64.5% of his passes for 1,250 yards, 10 touchdowns, and four interceptions, while Bryant Wesco Jr has caught 26 passes for 431 yards and five scores. Adam Randall has led the Clemson rushing attack with 368 yards and three touchdowns this year. 

Boston College Eagles Betting Preview

The Boston College Eagles are 1-4 (0-3) this season after they lost to Pittsburgh by a score of 48-7 in their last game. Boston College trailed 31-0 at halftime and 48-0 in the fourth, but did avoid the shutout with a late score. The Eagles were out gained by a total of 503-216, went 4-12 on third downs, and lost the turnover battle by a total of 3-0 in the game. Dylan Lonergan went 9-18 for 89 yards, while Jordan McDonald rushed five times for 31 yards. Kaelan Chudzinski led the BC receivers with three receptions for 70 yards and one score in the loss. The Boston College defense recorded two sacks and two tackles for loss in the game. 

Prior to that ugly loss, Boston College also lost to Cal, Stanford, and Michigan State, but did beat Fordham in their first game. The Eagles are averaging 31.4 points per game with 313.4 passing yards and 85.0 rushing yards per game, while they are allowing 31.6 points against per game this season. Dylan Lonergan has completed 67.4% of his passes for 1,277 yards, nine touchdowns, and three interceptions, while Lewis Bond has 38 receptions for 366 yards this year. Turbo Richard has led the BC ground game with 331 yards and four scores this season. 

Why the Clemson Tigers will win

Clemson has won 39 of its last 43 games in October.
Boston College has lost each of its last four games against non-AP-ranked teams.
The road team has covered the spread in four of Clemson’s last five games.
Boston College has failed to cover the spread in four of its last five October games against non-AP-ranked teams.

Total Points Facts

Ten of Boston College’s last 11 games against conference opponents at Alumni Stadium (Boston) have gone OVER the total points line.
Five of Clemson’s last six road games against non-AP-ranked teams have gone UNDER the total points line.

Matchup/League Facts

Boston College ranks 11th among FBS teams for passing yards per game this season (313.4).
Boston College ranks T125th among FBS teams for red zone percentage against this season (95.2).
Clemson ranks T114th among FBS teams for red zone percentage this season (76.9).
Clemson ranks T27th among FBS teams for 4th down conversion percentage against this season (37.5).

Clemson vs Boston College Prediction 

Clemson got back on the right track with a blowout win against North Carolina last week and they should have no trouble in this game either. The Tigers are just 2-3 on the season, but they have plenty of talent and a very solid quarterback. Boston College has lost four games in a row and they were just embarrassed by Pitt last week. I don’t think the BC offense will find enough success to keep this one close, so I am backing Clemson to win big on the road. 

David Racey is 58-44 (57%) in College Football this season and is one of the top College Football Handicappers on the site. Click here for his premium plays for the week!

David Racey's Pick: Clemson -14.5

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