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BYU vs East Carolina Prediction 9/20/2025 Today’s College Football Picks

Aug 30, 2025; Provo, Utah, USA; Brigham Young Cougars wide receiver Dominique McKenzie (89) reacts to scoring a touchdown against the Portland State Vikings during the fourth quarter at LaVell Edwards Stadium. Mandatory Credit: Rob Gray-Imagn Images

Aug 30, 2025; Provo, Utah, USA; Brigham Young Cougars wide receiver Dominique McKenzie (89) reacts to scoring a touchdown against the Portland State Vikings during the fourth quarter at LaVell Edwards Stadium. Mandatory Credit: Rob Gray-Imagn Images

BYU (2-0) vs East Carolina (2-1)

September 20, 2025 at 07:30 PM EDT

The Line: Betting Odds: East Carolina +6.5 — Over/Under: +49.5

(Get latest betting odds)

BYU and East Carolina  meet Saturday in Week 4 college football action from Dowdy-Ficklen Stadium. Here’s a BYU vs East Carolina prediction. We will look at this from a betting perspective and determine the best BYU Cougars vs East Carolina Pirates pick. We will examine:

The BYU Cougars’ recent form and player performance

The East Carolina Pirates’ recent form and player performance

Recent betting trends and streaks involving the Cougars 

Recent betting trends and streaks involving the Pirates

Recent betting trends in games played between BYU and East Carolina

A summary that ties it all together and produces a favorable betting outcome for the BYU vs East Carolina game.

Strong Start for BYU 


It has been a strong start for BYU to start the season and they sit with a 2-0 record. In the first game of the season, BYU faced off against Portland State 69-0 and in the last game against Stanford, BYU was able to secure the 27-3 victory. Against Stanford, BYU put up 332 total yards, and 175 yards through the air. Bear Bachmeier completed 17 of his 27 passes for 175 yards, zero touchdowns, and zero interceptions. LJ Martin finished with 18 carries for 110 yards. Chase Roberts finished with five catches for 84 yards. 

BYU on the season is averaging 48 points while their defense is giving up 1.50 points per game. The offense is ranked 10th in the league while the defense is the top-ranked defense in all of college football. In this game, the defense is going to need to step up in a big way and really try to put the pressure on the Pirates. 

Why BYU Will Beat East Carolina

  • BYU has won each of its last 13 September games as a favorite.
  • East Carolina has lost seven of its last eight September games as a home underdog.
  • BYU has covered the spread in each of its last six games in September.
  • East Carolina has failed to cover the spread in four of its last five September games as an underdog against non-AP-ranked teams.

Big Season for East Carolina?


East Carolina lost the first game of the season against NC State, but that was only by seven points total. Since that point, East Carolina has won back to back games in dominant fashion. East Carolina beat Campbell 56-3, and in the last game against Coastal Carolina, East Carolina secured the 38-0 victory. They scored 21 points in the 4th quarter to pull away, and really put a dagger in it. Katin Houser completed 28 of his 37 passes for 293 yards, two touchdowns, and one interception.  Running back London Montgomery finished with 15 carries for 59 yards. 

East Carolina on the season is averaging 37 points while their defense is giving up 9 points per game. The offense is ranked 41st while the defense is ranked 11th. Katin Houser has completed 83 of his 116 passes for 973 yards, five touchdowns, and one interception. 

Why East Carolina Will Beat BYU

  • East Carolina has won four of its last five games at Dowdy-Ficklen Stadium.
  • East Carolina has covered the spread in each of its last four games as an underdog.

BYU vs East Carolina Prediction


This is one of the biggest East Carolina games in years, and they are going to be fired up, and being at home is going to be a big advantage for this team. BYU hasn’t really been tested yet, and once thing we know about East Carolina is the offense good. Houser has been the real deal, and this is the biggest test for BYU for sure. I am not sold on this BYU defense being as good as the first couple of games have shown. If you want to play it safe and take the points, that is a fine bet, but I am going to go for the value, and that is the Pirates winning straight up. Back East Carolina on the money line. +230 is too much value to pass up. 

Shane Mickle's Pick: East Carolina ML +230

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