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Buffalo vs Penn State Prediction 9/19/2026 Today’s College Football Picks

Sep 12, 2026; Philadelphia, Pennsylvania, USA;  Penn State Nittany Lions wide receiver Chase Sowell (0) attempts to make a catch that would fall incomplete during the third quarter against the Temple Owls at Lincoln Financial Field.  Mandatory Credit: Matthew O'Haren-Imagn Images

Sep 12, 2026; Philadelphia, Pennsylvania, USA; Penn State Nittany Lions wide receiver Chase Sowell (0) attempts to make a catch that would fall incomplete during the third quarter against the Temple Owls at Lincoln Financial Field. Mandatory Credit: Matthew O'Haren-Imagn Images

MATCHUP Buffalo Bulls Penn State Nittany Lions
Team Records 1-1 2-0
Where Beaver Stadium, University Park, PA
When Saturday, September 19, 2026
Time 12:00 PM EDT
TV BTN
In this article, we will formulate a Buffalo vs Penn State Prediction for this College Football Week 3 matchup on Saturday, September 19th. Let’s take a look at the prediction for this College Football matchup.

Penn State Nittany Lions Preview


Penn State has a 2-0 record this season and are coming off a 27-9 road win against Temple. Offensively, Penn State averages 36 points per game, ranking 55th in the nation, while defensively, they allow 4.5 points per game, which is 1st. Penn State averages 451.5 total yards per game (296 passing and 155.5 rushing), while allowing 215 total yards per game (110 rushing and 105 passing).

Rocco Becht leads Penn State with 539 passing yards with 75.6% completed passes and 7 touchdowns. Carson Hansen leads the team in rushing yards with 132, while Koby Howard has a team-high 9 receptions for 229 receiving yards. Defensively, Tony Rojas has a team-high 14 total tackles (11 of them solo), while Tony Rojas leads the team with one sack.

Buffalo Bulls Preview


Buffalo has a 1-1 record this season and are coming off a 20-33 road loss against Florida International. Offensively, Buffalo averages 20.5 points per game, ranking 109th in the nation, while defensively, they allow 25 points per game, which is 78th. Buffalo averages 321 total yards per game (219 passing and 102 rushing), while allowing 408 total yards per game (113 rushing and 295 passing).

Elijah Holmes leads Buffalo with 253 passing yards with 57.4% completed passes and 3 touchdowns. Messiah Burch leads the team in rushing yards with 90, while Chance Morrow has a team-high 18 receptions for 221 receiving yards. Defensively, Stevie Bracey has a team-high 16 total tackles (8 of them solo), while Stevie Bracey leads the team with one sack.

Buffalo Bulls @ Penn State Nittany Lions Betting Trends: Week 3


Why the Penn State Nittany Lions will win

Why the Buffalo Bulls will win

Total Points Facts

Penn State Nittany Lions Player Prop Facts

Buffalo Bulls Player Prop Facts

Matchup/League Facts

Buffalo vs Penn State Prediction


In this Buffalo vs Penn State Prediction, Penn State is coming as -38.5 home favorites. Both teams are coming off opposite outcomes in the previous week and Penn State has been undefeated so far, having the best defense in the entire country, holding its opponents into just 4.5 points per game. On the flip side, Buffalo sits outside the top-100 in points scored and they have trouble producing offense in this game. They have also failed to cover the spread in both of their game this season, so I expect a comfortably victory for the home team. Take Penn State and lay the -38.5 points.

Nikos Lagouretos's Pick: Penn State -38.5

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