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Bowling Green vs Louisville Prediction 9/20/2025 Today’s College Football Picks

Louisville Cardinals defensive lineman Clev Lubin (50) and Louisville Cardinals defensive lineman Wesley Bailey (23) sack DUPLICATE***James Madison Dukes quarterback Alonza Barnett III (14) in the first half during the Louisville-James Madison college football game Friday September 5, 2025 at L&N Credit Union Stadium in Louisville, Kentucky.

Louisville Cardinals defensive lineman Clev Lubin (50) and Louisville Cardinals defensive lineman Wesley Bailey (23) sack DUPLICATE***James Madison Dukes quarterback Alonza Barnett III (14) in the first half during the Louisville-James Madison college football game Friday September 5, 2025 at L&N Credit Union Stadium in Louisville, Kentucky.

Bowling Green (2-1) vs Louisville (2-0)

September 20, 2025 at 12:00 PM EDT

The Line: Betting Odds: Louisville -26.5 — Over/Under: +52.5

(Get latest betting odds)

In this article, we will formulate a Bowling Green vs Louisville Prediction for this College Football Week 4 game on Saturday, September 20th at the L&N Federal Credit Union Stadium. Let’s take a look at the prediction for this College Football matchup.

Louisville Cardinals Preview

Louisville has a 2-0 record this season. Offensively, Louisville averages 39.5 points per game, which ranks 37th in the nation. Defensively, they allow 15.5 points per game, which ranks 35th in the nation. Louisville averages 403.0 total yards per game, with 171.0 rushing yards and 232.0 passing yards per game. They allow 206.5 total yards per game, 100.0 of them rushing and 106.5 passing yards per game.

Miller Moss leads Louisville with 30/48 completed passes and 374 total passing yards. He also adds 1 rushing touchdown. Isaac Brown leads the team in rushing yards, with 230 and 3 touchdowns, while Shaun Boykins adds 40 rushing yards. Chris Bell has a team-high 9 caught passes for a team-high 146 receiving yards, and has 1 touchdown. Caullin Lacy has caught 6 passes for 74 yards.

Defensively, TJ Quinn has a team-high 14 total tackles, 5 of them solo, and one sacks. Jabari Mack adds 2 total tackles and 1 interception. Clev Lubin leads Louisville in sacks, with 3.5, while Jabari Mack has a team-high 1 interception.

Bowling Green Falcons Preview

Bowling Green has a 2-1 record this season. Offensively, Bowling Green averages 23.0 points per game, which ranks 95th in the nation. Defensively, they allow 18.0 points per game, which ranks 46th in the nation. Bowling Green averages 314.0 total yards per game, with 137.7 rushing yards and 176.3 passing yards per game. They allow 320.7 total yards per game, 105.7 of them rushing and 215.0 passing yards per game.

Drew Pyne leads Bowling Green with 57/85 completed passes and 529 total passing yards. He also adds 9 rushing yards. Kaderris Roberts leads the team in rushing yards, with 152, while Chris McMillian adds 102 rushing yards and 1 touchdown. Jyrin Johnson has a team-high 10 caught passes for a team-high 138 receiving yards, and has 1 touchdown. Finn Hogan has caught 8 passes for 114 yards.

Defensively, Dorian Pringle has a team-high 27 total tackles, 17 of them solo, and 0.5 total sacks. Kal-El Pascal adds 21 total tackles, 13 of them solo and 1 interception. Eriq George leads Bowling Green in sacks, with 2, while Kal-El Pascal and Dorian Pringle each have 1 interception.

Bowling Green Falcons @ Louisville Cardinals Betting Trends: Week 4


Louisville Cardinals Player Prop Facts

  • Heading into Week 4, Isaac Brown ranks 1st amongst qualified players for Yards Per Carry (12.8) this season.

Bowling Green Falcons Player Prop Facts

  • Heading into Week 4, Jackson Kleather ranks T2nd amongst FBS players for made field goals (9) this season.

Matchup/League Facts

  • Louisville ranks 7th among FBS teams for passing yards allowed per game this season (106.5).
  • Louisville ranks 130th among FBS teams for 1st downs this season (39).
  • Bowling Green ranks 19th among FBS teams for time of possession per game this season (33:35).
  • Bowling Green ranks 115th among FBS teams for yards per game this season (314.0).

Bowling Green vs Louisville Prediction

This will be the first meeting between those two teams.

In this Bowling Green vs Louisville Prediction, Louisville is coming as -27-point home favorites. Both teams are coming off wins in their previous games, but Louisville has failed to cover the spread in both wins this season. On the flip side, Bowling Green has covered the spread in both games, but I don’t trust them on the road, as they have lost their only road game this season by 14 points. The Cardinals might not be covering, but they are playing excellent defense, holding their opponents into just 15.5 points per game, and I expect them to suppress a weak Falcons offense and win comfortably and cover the spread in this one.

Nikos Lagouretos's Pick: Louisville -26.5

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