Arizona (3-0) vs Iowa State (4-0)
September 27, 2025 at 07:00 PM EDT
The Line: Betting Odds: Iowa State -6 — Over/Under: +49
In this article we will formulate an Arizona vs Iowa State prediction for this College Football game on Saturday, September 27th at Jack Trice Stadium in Ames, Iowa. Let’s take a look at the prediction for this week 5 matchup.
Arizona Wildcats Betting Preview
The Arizona Wildcats are 3-0 (0-0) this year after they defeated Kansas State by a score of 23-17 in their last game. Arizona led 7-3 after the first quarter and 17-3 at halftime, but they ended up tied at 17 in the third, before pulling out the victory with two field goals. The Wildcats out gained Kansas State by a total of 412-193, went 8-18 on third downs, and lost the turnover battle by a margin of 2-1 in the game. Noah Fifita went 16-33 for 178 yards, while Ismail Mahdi rushed 22 times for 189 yards. Chris Hunter led the Arizona receivers with three catches for 37 yards in the win. The Arizona defense recorded one sack and nine tackles for loss in the victory.
Arizona opened the season with a win over Hawaii by a score of 40-6 and a win over Weber State by a score of 48-3. The Wildcats are averaging 37.0 points per game with 248.3 passing yards and 189.0 rushing yards per game, while they are allowing 8.7 points against per game this season. Noah Fifita has completed 59% of his passes for 712 yards and six touchdowns, while Javin Whatley has caught 13 passes for 237 yards and two scores. Ismail Mahdi has led the rushing attack for Arizona with 37 carries for 263 yards and one touchdown this year.
Iowa State Cyclones Betting Preview
The Iowa State Cyclones are 4-0 (1-0) this season after they defeated Arkansas State by a score of 24-16 in their last game. Iowa State led 9-0 after the first quarter and 17-10 at the half, but only led by one point in the fourth quarter, before adding a touchdown. The Cyclones out gained Arkansas State by a total of 452-382, went 5-11 on third downs, and tied the turnover battle at one in the game. Rocco Becht went 14-25 for 265 yards, one touchdown, and one interception, while Carson Hansen rushed 18 times for 116 yards. Xavier Townsend led the receivers with three catches for 92 yards in the win. The ISU defense recorded three sacks and seven tackles for loss in the victory.
Iowa State also has wins over Kansas State by a score of 24-21, South Dakota by a score of 55-7, and Iowa by a score of 16-13. The Cyclones are averaging 29.8 points per game with 222.0 passing yards and 161.0 rushing yards per game, while the defense has allowed 14.3 points against per game this season. Rocco Becht has completed 65% of his passes for 860 yards, seven touchdowns, and one interception, while Brett Eskildsen has caught seven passes for 162 yards and one touchdown. Carson Hansen has been the leading rusher for ISU with 54 carries for 252 yards this season.
Why Arizona will beat Iowa State
Arizona has won each of its last three games.
Arizona has covered the spread in four of its last five September games against top-15 AP-ranked teams.
Iowa State has failed to cover the spread in three of its last four games as a favorite.
Total Points Facts
Each of Arizona’s last five September games as an underdog have gone UNDER the total points line.
Four of Iowa State’s last five games at Jack Trice Stadium have gone UNDER the total points line.
Matchup/League Facts
Iowa State ranks T1st among FBS teams for 4th down conversion percentage this season (100.0).
Iowa State ranks T12th among FBS teams for Q3 opponent points per game this season (1.5).
Arizona ranks T6th among FBS teams for Q2 opponent points per game this season (1.0).
Arizona ranks 7th among FBS teams for H1 opponent points per game this season (3.0).
Arizona vs Iowa State Prediction
Iowa State comes into this matchup with the home field advantage, but they have barely escaped with wins over Iowa and Arkansas State in their last two games. Arizona also needed a late push to beat Kansas State, but this will be their first road game of the season. Both of these teams are coming off of a bye week, so they should be rested and ready to go. This should be a very good game to watch and I think both teams are pretty evenly matched, but I have not been impressed with Iowa State in their last two games. Give me the Wildcats and the points on the road.
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