Louisville vs Indiana Prediction - College Football Picks 9/16/23

Indiana Hoosiers (1-1) vs Louisville Cardinals (2-0)

Game Info: Saturday, September 16, 2023 at 12:00 pm (Lucas Oil Stadium)

Betting Odds: Indiana Hoosiers +10 -- Over/Under: 50.5 Click Here for the Latest Odds

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The Louisville Cardinals and Indiana Hoosiers face off on Saturday in a Week 3 college football showdown at Lucas Oil Stadium.

Louisville Looks for Third Win

Louisville has had a nice start to the season and they have won their first two games of the season. In the first game of the season, Louisville faced off against Georgia Tech and they were able to secure the 39-34 victory. In the last game against Missouri State, Louisville scored 56 points and the defense gave up zero points. Under center for Louisville is Jack Plummer and he completed 34 of his 53 passes for 494 yards, four touchdowns, and three interceptions. Jawhar Jordan has had 14 carries for 231 yards and three touchdowns.

Louisville Betting Trends

Louisville has won 17 of its last 18 September games as a favorite against non-AP-ranked teams.
Louisville has covered the spread in five of its last six games against non-conference opponents.
Six of Louisville's last seven games against non-AP-ranked teams have gone UNDER the total points line.

What’s This Year Look Like For Indiana?

The hopes is that this year is going to be better for Indiana, and they come into this game with a 1-1 record. In the first game of the season against Ohio State the defense wasn’t awful giving up 23 points, but the offense only managed three points. Last Friday they faced off against Indiana State, and Indiana was able to secure the 41-7 victory. In the last game, Tayven Jackson completed 18 of his 21 passes for 236 yards. Jaylin Lucas also finished with 10 carries for 86 yards and two touchdowns. In this game, Indiana needs the defense to step up in a big way.

Indiana Betting Trends

Indiana has lost 18 of its last 19 games as an underdog.
Indiana has failed to cover the spread in five of its last six games against non-conference opponents.
Each of Indiana's last four games against non-AP-ranked teams at neutral venues have gone UNDER the total points line.

Indiana vs Louisville Facts

Indiana was one of only 20 FBS teams to win 3+ games when trailing at HT last season.
Indiana was one of only 26 FBS teams to win 2+ games when trailing after Q3 last season.
Louisville ranked T16th among FBS teams for Q3 points allowed per game last season (3.7).
Louisville ranked T21st among FBS teams for Q2 win percentage last season (.615).

Shane’s Free Pick

Indiana is going to keep this game close. I was impressed with the way the defense looked against Ohio State in the first game, even though they lost. Louisville is no doubt a good offensive team, but Indiana’s defense is going to step up in a big way here. Louisville gave up 34 points in the first game of the season and they are going to struggle here against the Indiana offense. Back Indiana against the spread.