Louisville at Ole Miss - 9/6/21 College Football Picks and Prediction

Louisville at Ole Miss - 9/6/21 College Football Picks and Prediction Photo by Jamie Rhodes-USA TODAY Sports

Ole Miss Rebels (0-0) vs Louisville Cardinals (0-0)

Game Info: Monday, September 6, 2021 at 8:00 pm (Mercedes-Benz Stadium)

Betting Odds: Ole Miss Rebels -10 -- Over/Under: 76 Click Here for the Latest Odds

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The Louisville Cardinals and Ole Miss Rebels will square off at Mercedes-Benz Stadium this Monday night in College Football action.

The Louisville Cardinals finished last season with an overall record of 4-7 last season while finishing 12th in ACC play with a 3-4 conference record. Louisville struggled out of the gates last season, going 1-4 in their five games, however did end the season on a positive with an impressive 45-21 victory against the Wake Forest Demon Deacons. Offensively, Louisville averaged 29.5 ppg on 444.2 total yards per game (244.2 passing yds/g; 200 rushing yds/g). Louisville lost a bunch of weapons at the skill positions, however, do return QB Malik Cunningham who completed 64.1% of his passes for 2,617 yards, 20 TD, & 12 INT while also rushing for 609 yards & 7 TD’s. Cunningham’s top targets at the receiver positions will be Braden Smith (27 rec, 370 yards), Marshon Ford (25 rec, 309 yards, 6 TD), Justin Marshall (7 rec, 87 yards), & Jordan Watkins (8 rec, 57 yards). Leading the way for the Cardinals backfield will be Jalen Mitchell who finished last season with 347 yards & 2 TD’s on 52 carries.

Defensively, Louisville held their opponents to an average of 26.6 ppg on 369.1 total yards per game (189.2 passing yds/g; 179.9 rushing yds/g). Defensive Coordinator Bryan Brown has done a great job with the Louisville defense and will be led this season by LB C.J. Avery.

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The Ole Miss Rebels finished last season with an overall record of 5-5 while finishing 5th in the SEC West division with a 4-5 record. Ole Miss started off the season with just a 1-4 record, however, won 3 of their last 4 games to earn a Bowl bid and finished the season with an impressive 26-20 victory over the Indiana Hoosiers in the Outback Bowl. Offensively, Ole Miss averaged 39.2 ppg on 555.5 total yards per game (344.9 passing yds/g; 210.6 rushing yds/g). Offensively, Ole Miss will be led by QB Matt Corral who completed 70.9% of his passes for 3,337 yards, 29 TD, & 14 INT. Ole Miss no longer has Elijah Moore, however, has some solid weapons in Dontario Drummond (25 rec, 417 yards, 7 TD), Jonathan Mingo (1= rec, 379 yards, 3 TD), & Casey Kelly (8 rec, 115 yards, TD). Leading the way for the Rebels backfield will be Jerrion Ealy who finished last season with 745 rushing yards & 9 TD on 147 carries while also hauling in 155 receiving yards & 1 TD.

Defensively, Ole Miss allowed their opponents to average 38.3 ppg on 519.0 total yards per game (312.1 passing yds/g; 206.9 rushing yds/g). Ole Miss has brought in a bunch of new faces on the defensive end this season and will be led DE Sam Williams.

The Cardinals are 6-2 ATS in their last 8 games played on Week 1, however, are just 1-6 SU in their last 7 games when playing as the underdog. The Rebels are 4-1 SU in their last 5 games and 13-4 SU in their last 17 games when playing as the favorite.

This should be an entertaining game with a bunch of offense, however, between the fact that Louisville lost a bunch of impact players on the offensive end and that Ole Miss will be without their head coach, Lane Kiffin, who tested positive for COVID-19, I think this number has been set a bit too high. Louisville defense is better than what they get credit for and although I see a high scoring game, I think the play here is to take the under. Good Luck!

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The pick in this article is the opinion of the writer, not a PickDawgz site consensus.

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