Louisville vs. Clemson - 10/19/19 College Football Pick, Odds, and Prediction

Louisville vs. Clemson - 10/19/19 College Football Pick, Odds, and Prediction Photo by Matthew Emmons-USA TODAY Sports

Clemson Tigers (6-0) at Louisville Cardinals (4-2)

College Football: Saturday, October 19, 2019 at 12:00 pm (Papa John's Cardinal Stadium)

The Line: Louisville Cardinals +23.5 -- Over/Under: 61 Click Here for the Latest Odds

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The Clemson Tigers and the Louisville Cardinals will meet up on the college football gridiron Saturday. 

Clemson strolls into this game undefeated so far, going 6-0 with wins over Georgia Tech, Texas A&M, Syracuse, Charlotte, UNC and Florida State this season. 

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In the win over the Seminoles, Clemson QB Trevor Lawrence managed 170 yards, three TDs and an INT, and Travis Etienne added 127 rush yards. Leading the receivers there was Justin Ross’ 61 yards and two scores off five grabs. 

Over on the Louisville side, they’re 4-2 so far. Aside from losses versus Notre Dame and Florida State, the Cardinals have taken out Eastern KY, Western KY, Boston College and Wake Forest. 

In the Deacons win, Louisville QB Evan Conley posted 196 yards, two TDs and one INT, while also leading the rush with 79 yards and a score. Dez Fitzpatrick added 125 yards and two TDs receiving on five catches. 

Clemson is 4-0-1 ATS in their last five in October and 4-0 ATS in their last four on turf. The Tigers are 7-1 ATS in their last eight road games and 5-1 ATS versus a team with a winning record. 

Meanwhile, the Cardinals are 10-25 ATS in their last 35 overall and 7-19 ATS in their last 26 on tuff. Louisville is 5-14 ATS in their last 19 at home and 7-20 ATS in their last 27 in October. 

Clemson got a bit of a wake-up call in a 21-20 win over UNC a couple weeks back, but they got right back to it in the Florida State game, taking it 45-14 in yet another blowout. Five of the Tigers’ six wins have come by 14 points or more. There’s not much they can’t do. 

That said, Louisville has put up some nice points totals this year, including 62 against Wake and 41 over Boston College. I don’t think it’s crazy to believe that the Cardinals can get into this line and cover if they can hit a few big plays. 

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Andrew’s Pick Louisville Cardinals +23.5

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The pick in this article is the opinion of the writer, not a PickDawgz site consensus.

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